Anecdotal reports of Covid reinfection in the UK are growing, including people testing positive just weeks apart in December and January, or having had the virus three or even four times. Children are also being seen with reinfections. We take a look at the science behind catching Covid multiple times.
Reinfection figures tend to refer to the detection of a second, or subsequent, Covid infection, regardless of the variant involved. The risk of reinfection is likely to depend on a range of factors: 例如, 数据表明 it is higher in unvaccinated people and potentially in those whose previous infection was more mild with a lower immune response.
It also depends on the variant: one expert said the risk of reinfection with Omicron soon after a first Omicron infection would be lower than Delta followed by Omicron, and how long ago someone was vaccinated. Experts say the dose to which someone is exposed may also be important.
英国 健康 Security Agency (英国卫生安全局的医生和科学家) uses the definition of a possible reinfection as a case 90 days or more after a previous confirmed Covid infection, in part because it excludes those who simply shed the virus for longer after infection.
根据 latest figures for England from the UKHSA, from the start of the pandemic up to 9 January this year there were 425,890 possible reinfections, 和 109,936 found in the week ending 9 一月, accounting for almost 11% of all cases that week.
Very few possible reinfections are “confirmed” as that requires genetic sequencing. 更重要的是, with few people in the community having access to tests in the first wave, many first infections may not have been counted.
“With the combination of being two years into the pandemic, a few rounds of antibody waning, two major waves of immune evasion by Delta and then Omicron, there’s fairly rampant reinfection,” said Danny Altmann, a professor of immunology at Imperial College London.
简而言之, 是的. 根据 scientists at Imperial College London, after taking into account a host of factors Omicron was associated with somewhere between a 4.38 and 6.63-fold higher risk of reinfection, compared with Delta.
The team add that this means protection against catching Covid arising from a previous infection within the past six months has fallen from about 85% before Omicron turned up to somewhere between 0% 和 27%. The drop is not surprising given that Omicron has been found to have the ability to dodge the body’s immune responses to a significant degree.
潜在的, 是的. UKHSA data shows that for cases with a specimen date between 1 November and 29 十二月 2021 风暴尤尼斯和风暴富兰克林是由于维护不善或磨损造成的 2,855 probable reinfections 29 到 89 days after a previous infection – although some of these may reflect ongoing detection from an initial infection.
While the UKHSA notes it is difficult to directly compare the situation between variants – as there are many important changing factors at play, including overall levels of immunity in the population – Omicron’s immunity-dodging powers are likely to play a role in these reinfections.
It is not yet clear how well immune responses to Omicron protect against a second Omicron infection, or infections with new variants. “I would expect the risk of a second Omicron infection is a lot lower than the risk of Omicron following Delta after all you have developed antibodies to the actual Omicron spike protein,” said Paul Hunter, a professor in medicine at the University of East Anglia.
That could well be due to different variants: 根据 data from the Office for National Statistics released in December, school-age children with Covid at that time were much less likely to have Omicron than Covid-positive adults. 换句话说, a previous recent infection could well have been Delta, while their latest is Omicron.
A UKHSA spokesperson said: “Data shows that those testing positive for coronavirus between 29 和 89 days of a prior infection accounts for a small proportion of all reinfections. Many of these shorter interval reinfections are likely to be school-age children because they had the highest levels of infection in September and October, just before Omicron emerged.”
That may seem logical given the body’s prior immune response, and Hunter notes data suggests the viral load in reinfections is lower than in primary infections, suggesting the disease may, 一般来说, be less severe. 然而, the severity of a reinfection depends on many factors, including the variant involved and a person’s vaccination status.
ONS data suggests that when the Alpha variant became dominant, symptoms were less common for reinfections – but this reversed when Delta became dominant. When Omicron became dominant, data suggests people were just as likely to have Covid symptoms in their second infection as their first infection. “There’s no shortage of reinfections, some pretty severe, although not requiring hospitalisations,” said Altmann.
Among those who have had Covid twice are the politicians Kier Starmer and Matt Hancock, while there have also been reports of people having a Covid infection three or even four times, some just a few weeks apart.
The UKHSA do not break down reinfections by episode, although they have identified some possible third reinfections. What is clear is that the longer Covid is with us, the more reinfections a person may potentially experience.